- 中文名称
NSC 127943 | NSC 407276 |α-烟碱；3-（1-甲基-1H-吡咯-2-基）-吡啶
- 英文名字
- NSC 127943|NSC 407276|α-Nicotyrine; 3-(1-methyl-1H-pyrrol-2-yl)-pyridine
- 供应商
- Cayman Chemical
- 产品货号
- 16333-1
- 产品报价
- ￥询价/1mg
- 产品说明书
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- 购买方式
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- 产品新闻
- 背景资料
- β-Nicotyrine is an alkaloid metabolite of nicotine as well as a major product of its pyrolysis.{26726,26727} It binds comparably to two cytochrome P450 (CYP) isoforms, CYP2A6 and CYP2A13 (Kis = 7.5 and 5.6 µM, respectively), which are prominently involved in the metabolism of xenobiotics in the airways.{26724} However, β-nicotyrine appears to more effectively inactivate CYP2A6, leaving only 49% activity after a 10 minute exposure with 20 µM β-nicotyrine, as opposed to 87% remaining activity for CYP2A13 treated identically.{26722} Presumably through this effect, β-nicotyrine inhibits DNA strand breaks induced by the genotoxic tobacco metabolite (4-(methylnitrosamino)-1-(2-pyridyl)-1-butanone), which is bioactivated by CYP2A isoforms.{26723}
- 产品描述
- An alkaloid metabolite of nicotine as well as a major product of its pyrolysis; binds comparably to CYP2A6 and CYP2A13 (Kis = 7.5 and 5.6 µM, respectively), but appears to more effectively inactivate CYP2A6
- 产品形式
- A crystalline solid
- 保存建议
- 建议您在收到Cayman Chemical品牌的β-Nicotyrine (1 mg)产品后置于-20度保存，产品有效期为730天.
- 其他
- Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.
- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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