中文名称

Erismodegib | NVP-LDE225 | Sonidegib; rel-N- [6-[（2R，6S）-2,6-二甲基-4-吗啉基] -3-吡啶基] -2-甲基-4'-（三氟甲氧基）-[1,1'-联苯]- 3-羧酰胺，二磷酸

英文名字

Erismodegib|NVP-LDE225|Sonidegib; rel-N-[6-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide, diphosphate

供应商

Cayman Chemical

产品货号

16263-10

产品报价

￥询价/10mg

产品说明书

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购买方式

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产品新闻

背景资料

Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of the GPCR-like receptor, Smoothened (SMO).{21774} In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers.{27050} LDE225 is an Hh signaling pathway inhibitor that acts by antagonizing SMO (IC50s = 1.3 and 2.5 nM for mouse and human, respectively).{27243} A dose of 20 mg/kg/day LDE225 has been shown to penetrate the blood brain barrier, inhibit Gli1 mRNA expression, and prevent tumor growth in a medulloblastoma allograft mouse model.{27243} This compound has been investigated in phase II clinical trials for potential treatment of several Hh pathway activated cancers.

产品描述

An Hh signaling pathway inhibitor that acts by antagonizing SMO (IC50s = 1.3 and 2.5 nM for mouse and human, respectively); inhibits Gli1 mRNA expression and prevents tumor growth in a medulloblastoma allograft mouse model at 20 mg/kg/day

产品形式

A crystalline solid

保存建议

建议您在收到Cayman Chemical品牌的LDE225 (phosphate) (10 mg)产品后置于-20度保存，产品有效期为730天.

其他

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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