中文名称

（6S，9aS）-六氢-6-[（（4-羟基苯基）甲基] -8-（1-萘甲基）-4,7-二氧代-N-（苯基甲基）-2H-吡嗪并[1,2-a]嘧啶-1（6H）-羧酰胺

英文名字

(6S,9aS)-hexahydro-6-[(4-hydroxyphenyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide

供应商

Cayman Chemical

产品货号

16257-10

产品报价

￥询价/10mg

产品说明书

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购买方式

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产品新闻

背景资料

ICG-001 is a small molecule inhibitor of β-catenin/cyclic AMP responsive element binding protein binding protein (CBP)-mediated transcription (IC50 = 3 µM).{26952} By binding CBP, thus blocking interaction with β-catenin, it selectively induces apoptosis in transformed colon cells but not in normal cells and prevents the growth of colon carcinoma cells at 25 µM in vitro.{26952,26951} ICG-001 has been used to specifically disrupt the β-catenin pathway in studying epithelial-mesenchymal transition during pulmonary fibrosis.{26949,26953} Additionally, ICG-001 disruption of Wnt/β-catenin signaling has been studied in the context of regulating cancer stem cells.{26950}

产品描述

A small molecule inhibitor of β-catenin/cyclic AMP responsive element binding protein binding protein (CBP)-mediated transcription (IC50 = 3 µM); selectively induces apoptosis in transformed colon cells but not in normal cells and prevents the growth of colon carcinoma cells at 25 µM in vitro

产品形式

A crystalline solid

保存建议

建议您在收到Cayman Chemical品牌的ICG-001 (10 mg)产品后置于-20度保存，产品有效期为730天.

其他

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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