Benztropine is a synthetic compound derived from the combination of atropine and diphenhydramine that acts centrally to antagonize M1 muscarinic acetylcholine receptors (Ki = 0.59 nM in rat).{26585} It can also increase the availability of dopamine by inhibiting uptake through the dopamine transporter (Ki = 160 nM).{20213,26584} Benztropine has been used in the management of Parkinson’s disease symptoms to address involuntary tremor and dystonia.{26582} It has also been identified as a functional inhibitor of acid sphingomyelinase.{26583}
产品描述
A centrally acting M1 muscarinic acetylcholine receptor antagonist (Ki = 0.59 nM in rat) that also inhibits dopamine uptake through the dopamine transporter (Ki = 160 nM); used in the management of Parkinson’s disease symptoms to address involuntary tremor and dystonia
