中文名称

3-Ingenyl Angelate | Ingenol Mebutate | PEP005 | Picato; （2Z）-（1aR，2S，5R，5aS，6S，8aS，9R，10aR）-1a，2,5,5a，6,9,10,10a-八氢-5,5a-二羟基-4-（羟甲基） ）-1,1,7,9-四甲基-11-氧代-1H-2,8a-甲亚甲基环戊基[a]环丙基[e]环癸烯-6基酯2-甲基-2-丁烯酸

英文名字

3-Ingenyl Angelate|Ingenol Mebutate|PEP005|Picato; (2Z)-(1aR,2S,5R,5aS,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a-octahydro-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl ester 2-methyl-2-butenoic acid

供应商

Cayman Chemical

产品货号

16207-5

产品报价

￥询价/5mg

产品说明书

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购买方式

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产品新闻

背景资料

Ingenol-3-angelate is a hydrophobic diterpene ester that can be isolated from the euphorb E. peplus. It rapidly induces cell death in proliferating keratinocytes through plasma membrane and mitochondrial disruption, although it can also initiate apoptosis in some cancer cell lines (LD90 = ~ 190 µM).{26474} Secondarily, ingenol-3-angelate causes inflammation due, at least in part, to activation of PKC, leading to antibody-dependent cellular cytotoxicity.{26475,26472,23438} These actions have relevance in diminishing actinic keratosis and, possibly, other cancers of the skin.{21836,26473}

产品描述

A hydrophobic diterpene ester that rapidly induces cell death in proliferating keratinocytes through plasma membrane and mitochondrial disruption; causes inflammation due, at least in part, to activation of PKC, leading to antibody-dependent cellular cytotoxicity

产品形式

A crystalline solid

保存建议

建议您在收到Cayman Chemical品牌的Ingenol-3-angelate (5 mg)产品后置于-20度保存，产品有效期为730天.

其他

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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