Cytarabine is a nucleoside analog that differs from cytosine by the presence of a hydroxyl group at the 2’ position of the sugar residue. It is triphosphorylated in vivo to produce ara-CTP, a competitive inhibitor of DNA polymerases α and β (Kis = 4 and 32 µM, respectively).{26180,26181,26183} At low concentrations, ara-CTP is incorporated into DNA, slowing but not stopping DNA synthesis.{26184} Cytarabine is effective in the treatment of leukemias.{26184} It can also have antiviral actions on certain types of viruses.{26182}
产品描述
A nucleoside analog that differs from cytosine by the presence of a hydroxyl group at the 2’ position of the sugar residue; triphosphorylated in vivo to produce ara-CTP, a competitive inhibitor of DNA polymerases α and β (Kis = 4 and 32 µM, respectively)
