PGF2.alpha.-NEt2 is an analog of PGF2.alpha. in which the C-1 carboxyl group has been modified to an N-diethyl amide. PG esters have been shown to have ocular hypotensive activity.{8837} PG N-ethyl amides were recently introduced as alternative PG hypotensive prodrugs.{8941}Bovine and human corneal tissue converts the N-ethyl amides of various PGs to the free acids with a conversion efficiency of about 4 ug/g corneal tissue/hr.{9311} However
