中文名称

阿沃达特 N- [2,5-双（三氟甲基）苯基] -2,4aR，4bS，5,6,6aS，7S，8,9,9aS，9bS，10,11,11aR-十四氢-4a，6a-二甲基- 2-氧代-1H-茚并[5,4-f]喹啉-7-羧酰胺

英文名字

Avodart; N-[2,5-bis(trifluoromethyl)phenyl]-2,4aR,4bS,5,6,6aS,7S,8,9,9aS,9bS,10,11,11aR-tetradecahydro-4a,6a-dimethyl-2-oxo-1H-indeno[5,4-f]quinoline-7-carboxamide

供应商

Cayman Chemical

产品货号

15956-5

产品报价

￥询价/5mg

产品说明书

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购买方式

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产品新闻

背景资料

5α-reductase catalyzes the NADPH-dependent reduction of Δ4,5 double bonds in several steroid substrates, including testosterone (Item No. 15645), which is converted to dihydrotestosterone, the primary mediator of prostate growth.{23863} The 5α-reductase enzymes responsible for the reduction of testosterone to dihydrotestosterone exist as two forms: type I, which occurs in the skin, liver, and ventral prostate and type II, which is expressed in ventral prostate, epididymis, and other reproductive tissues.{23862} Dutasteride is a time-dependent, dual inhibitor of 5α-reductase (apparent Kis = 17 and 4.3 nM at 10 and 30 minute reaction times, respectively) that is frequently used in the treatment of benign prostatic hyperplasia.{25831,25832} Compared to finasteride (Item No. 14938), a selective inhibitor of type II 5α-reductase, dutasteride has a greater terminal half-life (1 vs. 14 hours in rat, respectively) and is more effective at decreasing serum levels of dihydrotestosterone at single doses > 10 mg.{25832} Dutasteride has also been used as a strategy to reduce androgen levels related to prostate tumor burden on androgen receptor activity.{25833}

产品描述

A time-dependent, dual inhibitor of 5α-reductase (apparent Kis = 17 and 4.3 nM at 10 and 30 minute reaction times, respectively) that is frequently used in the treatment of benign prostatic hyperplasia

产品形式

A crystalline solid

保存建议

建议您在收到Cayman Chemical品牌的Dutasteride (5 mg)产品后置于-20度保存，产品有效期为730天.

其他

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

注意

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