中文名称

5-[（4-乙基苯基）亚甲基] -2-硫代-4-噻唑烷酮

英文名字

5-[(4-ethylphenyl)methylene]-2-thioxo-4-thiazolidinone

供应商

Cayman Chemical

产品货号

15929-10

产品报价

￥询价/10mg

产品说明书

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购买方式

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产品新闻

背景资料

The Myc proto-oncogenes interact with Max to form a dimer that regulates gene transcription. The protein c-Myc, in particular, promotes gene expression relevant to cell growth and thus drives cancer. 10058-F4 is a cell-permeable thiazolidinone that inhibits the dimerization of c-Myc and Max at 64 µM, preventing c-Myc-dependent gene expression and cell proliferation.{25765} It induces cell cycle arrest, apoptosis, and myeloid differentiation at 100 µM in human acute myeloid leukemia cells.{25762} 10058-F4 is rapidly metabolized in mice when given intravenously, limiting its effects on tumors in vivo.{25761} In addition to c-Myc, 10058-F4 inhibits the nuclear Myc protein, n-Myc, at 50 µM, inducing arrest, apoptosis, and differentiation in neuroblastoma cells overexpressing the gene for n-Myc.{25763} This compound can be used to delineate novel actions of Myc proteins, especially those related to lipid and glucose metabolism.{25763,25764}

产品描述

A cell-permeable inhibitor of the dimerization of c-Myc and Max at 64 µM, preventing c-Myc-dependent gene expression and cell proliferation; induces cell cycle arrest, apoptosis, and myeloid differentiation at 100 µM in human acute myeloid leukemia cells; inhibits the nuclear Myc protein, n-Myc, at 50 µM

产品形式

A crystalline solid

保存建议

建议您在收到Cayman Chemical品牌的10058-F4 (10 mg)产品后置于-20度保存，产品有效期为730天.

其他

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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