Edrophonium (chloride) is an acetylcholinesterase (AChE) inhibitor that is known to prevent the breakdown of the neurotransmitter acetylcholine by binding specifically to its catalytic site.{19397} It has been shown to inhibit AChE activity in human red blood cells, purified calf forebrain, and purified octopus brain with Ki values of 0.2, 0.2, and 0.4 µM, respectively.{25818} Edrophonium is often used as part of a battery of pharmacological tests to confirm a diagnosis of the autoimmune neuromuscular junction disorder, myasthenia gravis.{25819}
产品描述
An AChE inhibitor (Kis = 0.2 - 0.4 µM) that is known to prevent the breakdown of the neurotransmitter acetylcholine by binding specifically to its catalytic site; used as part of a battery of pharmacological tests to confirm a diagnoses of myasthenia gravis
