Norfluoxetine is an active metabolite of the antidepressant fluoxetine that inhibits serotonin uptake with a pKi value of 7.35.{25776} The S-enantiomer of norfluoxetine has 20-times higher serotonin reuptake blocking potency than the R-enantiomer (pKis = 7.86 versus 6.51, respectively).{25777,25776}
产品描述
An active metabolite of the antidepressant fluoxetine that inhibits serotonin uptake (pKi = 7.35); the S-enantiomer of norfluoxetine is 20-fold more potent as an SSRI than the R-enantiomer (pKis = 7.86 versus 6.51, respectively)