epi-Testosterone is the 17α-hydroxy epimer of testosterone (Item No. 15645) and an endogenous steroid. It is an antagonist at the androgen receptor (IC50 = 15 nM), interfering with signaling of testosterone or its metabolite at that receptor.{25834,25835} epi-Testosterone also weakly inhibits 5α-reductase, affording 24% inhibition of the conversion of testosterone to 5α-dihydrotestosterone at 10 µM.{25837} The ratio of testosterone to epi-testosterone is commonly used in doping tests to detect enhanced testosterone levels.{22425,25836}
产品描述
An endogenous steroid that acts as an antagonist at the androgen receptor (IC50 = 15 nM), interfering with signaling of testosterone or its metabolite at that receptor; weakly inhibits 5α-reductase, affording 24% inhibition of the conversion of testosterone to 5α-dihydrotestosterone at 10 µM
