- 中文名称
Dipirona |美他唑；1-[（2,3-二氢-1,5-二甲基-3-氧代-2-苯基-1H-吡唑-4-基）甲氨基]-甲磺酸，钠盐
- 英文名字
- Dipirona|Metamizol; 1-[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]-methanesulfonic acid, monosodium salt
- 供应商
- Cayman Chemical
- 产品货号
- 15771-25
- 产品报价
- ￥询价/25g
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- Metamizole (sodium salt) is a nonopioid prodrug that is rapidly hydrolyzed to the metabolites 4-methylaminoantipyrine (MAA) and 4-aminoantipyrine (AA), which have analgesic and antipyretic effects.{25749} MAA has been shown to inhibit COX activity 8-9-fold more potently than AA (COX-1: IC50s = 2.6 and 20.8 µM, respectively, and COX-2: IC50s = 4.7 and 41.8 µM, respectively).{25748} These metabolites can be further acylated with arachidonic acid (Item No. 90010) to form compounds that can bind to central and peripheral cannabinoid (CB1 and CB2) receptors and TRPV1 receptors at low micromolar concentrations.{25749,25750} Metamizole is associated with a risk of agranulocytosis and has been banned against using in clinical and pharmacological settings in the United States since 1977.{25751,25747}
- 产品描述
- An analgesic and antipyretic prodrug that is rapidly hydrolyzed to the metabolites 4-methylaminoantipyrine and 4-aminoantipyrine, which both inhibit COX activity (COX-1: IC50s = 2.6 and 20.8 µM, respectively, and COX-2: IC50s = 4.7 and 41.8 µM, respectively); binds to CB1 and CB2 receptors and TRPV1 receptors at low micromolar concentrations when acylated with arachidonic acid
- 产品形式
- A crystalline solid
- 保存建议
- 建议您在收到Cayman Chemical品牌的Metamizole (sodium salt) (25 g)产品后置于-20度保存，产品有效期为730天.
- 其他
- Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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