- 中文名称
AG-014447；8-氟-1,3,4,5-四氢-2- [4-[（（甲基氨基）甲基]苯基] -6H-吡咯并[4,3,2-ef] [2]苯并ze庚因-6-
- 英文名字
- AG-014447; 8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one
- 供应商
- Cayman Chemical
- 产品货号
- 15643-10
- 产品报价
- ￥询价/10mg
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- Poly(ADP-ribose) polymerases (PARPs) are activated by DNA single- and double-strand breaks and promote repair of DNA damage through the relaxation of chromatin and recruitment of other repair proteins.{20554,20553,20549} Inhibition of PARP activity has been linked to synthetic lethality in cells with mutations in BRCA1 or BRCA2 and is used as a therapeutic strategy to selectively target cancers.{20680,20677} Rucaparib is a potent, cell-permeable inhibitor of PARP-1 (Ki = 50 values ranging from 1.3-5.5 μM.{20679} At 25 mg/kg, rucaparib arrests tumor growth in mice bearing epigenetically silenced BRCA1 UACC3199 xenograft tumors.{20679} It has been shown to increase efficacy of temozolomide in medulloblastoma cells and xenografts.{20678}
- 产品描述
- A potent, cell-permeable inhibitor of PARP1 (Ki = 50s = 1.3-5.5 μM); arrests tumor growth in mice bearing epigenetically silenced BRCA1 UACC3199 xenograft tumors
- 产品形式
- A crystalline solid
- 保存建议
- 建议您在收到Cayman Chemical品牌的Rucaparib (10 mg)产品后置于-20度保存，产品有效期为730天.
- 其他
- Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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