Elaiophylin is a macrodiolide antibiotic that can be isolated from various strains of Streptomyces.{25429,25428} It displays in vitro anti-protozoal activity against both Plasmodium and Trypanosoma (IC50s = 370 and 460 ng/ml, respectively) and cytotoxicity against human fetal lung fibroblast MRC-5 cells (IC50 = 870 ng/ml).{25430} Elaiophylin alone has no activity against Candida, although it enhances the anti-fungal activity of rapamycin (Item No. 13346).{25428} Elaiophylin also forms stable, long-lasting ion channels in bilayer membranes that are selective for cations.{25431}
产品描述
A macrodiolide antibiotic that displays anti-protozoal activity against both Plasmodium and Trypanosoma (IC50s = 370 and 460 ng/ml, respectively) and cytotoxicity against MRC-5 cells (IC50 = 870 ng/ml); enhances the anti-fungal activity of rapamycin
