AG-538 is a substrate competitive inhibitor of the insulin-like growth factor-1 (IGF-1) receptor kinase (IC50 = 61 nM).{25699} It has been shown to inhibit IGF-1 receptor autophosphorylation and to disrupt the activation of downstream targets Akt (IC50 = 19 µM) and Erk2 in intact cells.{25699} AG-538 inhibits the growth of breast cancer-derived cell lines at IC50 values ranging from 25-79 µM.{25699}
产品描述
An IGF-1 receptor inhibitor (IC50 = 61 nM) that prevents IGF-1 receptor autophosphorylation and disrupts the activation of downstream targets Akt (IC50 = 19 µM) and Erk2 in intact cells; inhibits the growth of breast cancer-derived cell lines (IC50s = 25-79 µM)
