中文名称

4-[（（1E）-2-（2-氨基-4-羟基-5-甲基苯基）二氮烯基] -N-2-吡啶基-苯磺酰胺

英文名字

4-​[(1E)-2-​(2-​amino-4-​hydroxy-​5-​methylphenyl)​diazenyl]-​N-2-​pyridinyl-benzenesulfonamide

供应商

Cayman Chemical

产品货号

15484-10

产品报价

￥已停产

产品说明书

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购买方式

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产品新闻

背景资料

The bromodomain and extra terminal domain (BET) family of proteins including BRD2, BRD3, and BRD4 play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interaction by controlling the assembly of histone acetylation-dependent chromatin complexes.{26201} Each protein contains pairs of bromodomains, usually referred to as BD1 and BD2.{26201,19950} MS-436 is a potent BRD4 bromodomain inhibitor that binds BD1 more avidly than BD2 (Ki values are 30-50 nM for BD1 and 340 nM for BD2).{24885} It also binds BD1 and BD2 of BRD3 (Kis = 100 and 140 nM, respectively) as well as bromodomains of other BET and non-BET proteins with low micromolar affinities.{24885} MS-436 blocks BRD4-dependent transcriptional activity in LPS-stimulated RAW264.7 macrophages, inhibiting NO and IL-6 production (IC50s = 3.8 and 4.9 µM, respectively).{24885}

产品描述

A potent BRD4 bromodomain inhibitor that binds BD1 more avidly than BD2 (Ki values are 30-50 nM for BD1 and 340 nM for BD2); also binds BD1 and BD2 of BRD3 (Kis = 100 and 140 nM, respectively) as well as bromodomains of other BET and non-BET proteins with low micromolar affinities

产品形式

A crystalline solid

保存建议

建议您在收到Cayman Chemical品牌的MS-436 (10 mg)产品后置于-20度保存，产品有效期为730天.

其他

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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