Brimonidine is a selective α2-adrenergic receptor agonist that lowers intraocular pressure by decreasing aqueous humor synthesis and increasing drainage through uveoscleral outflow.{25330} By stimulating α2-adrenergic receptors coupled to their G proteins (Ki = 183 nM), brimonidine inhibits adenylate cyclase activity and reduces cAMP.{25331} Furthermore, at 1 mg/kg/day brimonidine has been shown to protect rat retinal ganglion cells against glutamate excitotoxicity by inhibiting glutamate release and blocking the upregulation of NDMA receptor 1 and 2A protein expression.{25329}
产品描述
A selective α2-adrenergic receptor agonist (Ki = 183 nM) that lowers intraocular pressure by decreasing aqueous humor synthesis and increasing drainage through uveoscleral outflow; protects rat retinal ganglion cells against glutamate excitotoxicity by inhibiting glutamate release and blocking the upregulation of NDMA receptor 1 and 2A protein expression
