CAY10683 is a potent histone deacetylase (HDAC) inhibitor isolated from the cyanobacterium Symploca.{24818} It inhibits HDAC2 and HDAC6 with IC50 values of 0.119 and 434 nM, respectively, and is without effect against HDAC4 (IC50 = > 1,000 nM).{24818} CAY10683 inhibits the growth of HCT-116 colon cancer cells and HuT-78 cutaneous T cell lymphoma cells (GI50 = 29.4 and 1.4 μM, respectively) more effectively than human dermal fibroblasts (GI50 = > 100 μM).{24818}
产品描述
A potent HDAC inhibitor that inhibits HDAC2 and HDAC6 with IC50 values of 0.119 and 434 nM; ineffective against HDAC4 (IC50 = > 1,000 nM); inhibits the growth of HCT-116 cells and HuT-78 cells (GI50 = 29.4 and 1.4 μM, respectively) more effectively than human dermal fibroblasts (GI50 = > 100 μM)
