中文名称

（7bS）-5,5aR，6,7,7aR，7b-六氢-7b-羟基-4S-甲基茚满[1,7-bc]呋喃-2（4H）-

英文名字

(7bS)-5,5aR,6,7,7aR,7b-hexahydro-7b-hydroxy-4S-methyl-indeno[1,7-bc]furan-2(4H)-one

供应商

Cayman Chemical

产品货号

15387-500

产品报价

￥询价/500ug

产品说明书

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购买方式

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产品新闻

背景资料

Galiellalactone is a fungal metabolite isolated from the ascomycetes G. rufa strain A75-86 and A111-95 that inhibits IL-6-mediated JAK/STAT signal transduction in HepG2 cells with an IC50 value of 0.25-0.5 μM.{24943} The selectivity of this compound is achieved by its ability to block the binding of activated STAT3 dimers to their DNA binding sites without affecting phosphorylation of the STAT3 transcription factor.{24943} At 10-50 μM, galiellalactone exhibits dose-dependent growth inhibitory effects on prostate cancer stem cell-like cells expressing active STAT3, suggesting it may be a useful therapeutic approach to control JAK/STAT signaling.{24944}

产品描述

A fungal metabolite that inhibits IL-6-mediated JAK/STAT signal transduction in HepG2 cells (IC50 = 0.25-0.5 μM) by blocking the binding of activated STAT3 dimers to DNA; 10-50 μM exhibits dose-dependent growth inhibitory effects on prostate cancer stem cell-like cells expressing active STAT3

产品形式

A white lyophilized powder

保存建议

建议您在收到Cayman Chemical品牌的Galiellalactone (500 µg)产品后置于-20度保存，产品有效期为730天.

其他

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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