In eukaryotes, a set of initiation factors (eIFs) interact with ribosomal subunits to initiate mRNA translation.{25211} A major step in initiation is the assembly of a large multiprotein complex that includes the cap-binding protein eIF4E and the multidomain adaptor protein eIF4G.{25211} 4EGI-1 is an inhibitor of the initiation of translation that blocks the interaction of eIF4G with eIF4E (KD = 25 μM).{25208} It directly binds eIF4E, competitively inhibiting an association with eIF4G that is necessary for cap-dependent translation.{25208} 4EGI-1 prevents the expression of oncogenic proteins in mammalian cancer cells, leading to apoptosis.{25208,25207,25213} Research with this inhibitor supports a role for normal eIF4E/eIF4G interaction in memory consolidation and excess interaction in autism spectrum disorders.{25212,25210,25206} 4EGI-1 also blocks translation in some viruses that do not require eIF4E or a cap structure for initiation.{25209}
产品描述
An inhibitor of the initiation of translation that blocks the interaction of eIF4G with eIF4E (KD = 25 μM); prevents the expression of oncogenic proteins in mammalian cancer cells, leading to apoptosis; blocks translation in some viruses that do not require eIF4E or a cap structure for initiation
