Harringtonine is a natural alkaloid that inhibits protein synthesis at low micromolar concentrations.{25658} It immobilizes ribosomes immediately after the initiation of translation.{25659,25658} While harringtonine has drawn some interest in mitigating cancer, its homolog homoharrington is more effective, particularly for chronic myelogenous leukemia.{25660,25662,25661} The ability of harringtonine to immobilize initiating ribosomes can be used to capture ribosome-protected mRNA fragments for evaluating translation.{25659}
产品描述
A natural alkaloid that inhibits protein synthesis at low micromolar concentrations; immobilizes ribosomes immediately after the initiation of translation
