Kallikreins are a class of serine proteases that affect the release of vasodepressor peptides or kinins from a plasma substrate. PPACKII is a specific and irreversible inhibitor of glandular and plasma kallikreins.{24966} At micromolar concentrations it has been shown to prevent apolipoprotein proteolysis in dextran sulfate-precipitated human plasma LDL and to inhibit serum atrial natriuretic peptide cleavage.{2805} PPACK II has also been reported to inactivate the amidolytic activity of native human Hageman Factor (Factor XII) at 5.3 μM.{24967}
产品描述
An irreversible inhibitor of glandular and plasma kallikreins that has been shown to prevent apolipoprotein proteolysis in dextran sulfate-precipitated human plasma LDL and to inhibit serum atrial natriuretic peptide cleavage
