中文名称

7-羟基香豆素-3-羧酸乙酯; 7-羟基-2-偶氮-2H-1-苯并吡喃-3-羧酸乙酯

英文名字

7-hydroxycoumarin-3-Carboxylic Acid ethyl ester; 7-hydroxy-2-ozo-2H-1-benzopyran-3-carboxylic acid, ethyl ester

供应商

Cayman Chemical

产品货号

15352-50

产品报价

￥询价/50mg

产品说明书

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购买方式

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产品新闻

背景资料

Cells that are rapidly proliferating or hypoxic emphasize glycolysis over oxidative phosphorylation to meet energy needs.{22136,26415} During glycolysis, fructose 6-phosphate (F6P) is phosphorylated by 6-phosphofructo-2-kinases (PFKs) to generate fructose 2,6-bisphosphate. As PFK family members also mediate the reverse reaction as fructose 2,6-bisphosphatases, these enzymes are known as PFKFB family members. Notably, PFKFB3 is overexpressed in a wide variety of cancer cell lines.{27006} YZ9 is a potent inhibitor of PFKFB3, with an IC50 value of 183 nM in vitro.{27006} It avidly competes with F6P at PFKFB3 (Ki = 94 nM).{27006} YZ9 is also cell permeable, inhibiting the growth of HeLa cells with a GI50 value of 2.7 µM.{27006}

产品描述

A potent inhibitor of the glycolysis enzyme PFKFB3, with an IC50 value of 183 nM in vitro; avidly competes with F6P at PFKFB3 (Ki = 94 nM); cell permeable, inhibiting the growth of HeLa cells with a GI50 value of 2.7 µM

产品形式

A crystalline solid

保存建议

建议您在收到Cayman Chemical品牌的YZ9 (50 mg)产品后置于-20度保存，产品有效期为730天.

其他

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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