中文名称

CD336 | NSC 608001 | Ro 40-6055; 4-[[（（5,6,7,8-四氢-5,5,8,8-四甲基-2-萘基）羰基]氨基]-苯甲酸酸

英文名字

CD336|NSC 608001|Ro 40-6055; 4-​[[(5,​6,​7,​8-​tetrahydro-​5,​5,​8,​8-​tetramethyl-​2-​naphthalenyl)​carbonyl]​amino]​-benzoic acid

供应商

Cayman Chemical

产品货号

15261-5

产品报价

￥询价/5mg

产品说明书

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购买方式

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产品新闻

背景资料

AM580 is a retinoic acid receptor agonist that is selective for RARα (Kd = 8 nM; AC50 = 0.36 nM) compared to RARβ (Kd = 131 nM; AC50 = 24.6 nM) and RARγ (Kd = 450 nM; AC50 = 27.9 nM).{24736} It demonstrates greater specific binding to RARα compared to retinoic acid (Item No. 11017), which exhibits little selectivity across RARα, β, or γ.{24736,18516,20156} AM580 has been used in combination with the GSK3β inhibitor CHIR99021 (Item No. 13122) to efficiently induce differentiation of human induced pluripotent stem cells into immediate mesoderm.{25645} It can also inhibit the proliferation of various tumor cells, inhibiting survival signaling pathways and inducing apoptosis.{25647,25646}

产品描述

A retinoic acid receptor agonist that is selective for RARα (Kd = 8 nM; AC50 = 0.36 nM) compared to RARβ (Kd = 131 nM; AC50 = 24.6 nM) and RARγ (Kd = 450 nM; AC50 = 27.9 nM); used in combination with the GSK3β inhibitor CHIR99021 to induce differentiation of human induced pluripotent stem cells

产品形式

A crystalline solid

保存建议

建议您在收到Cayman Chemical品牌的AM580 (5 mg)产品后置于-20度保存，产品有效期为730天.

其他

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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