中文名称

PORCN抑制剂III | Wnt通路抑制剂XIX; N-（5-苯基-2-吡啶基）-2-[（（3,4,6,7-四氢-4-氧代-3-苯基噻吩并[3,2-d]嘧啶-2-基）硫代]-乙酰胺

英文名字

PORCN Inhibitor III|Wnt Pathway Inhibitor XIX; N-(5-phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide

供应商

Cayman Chemical

产品货号

15243-5

产品报价

￥询价/5mg

产品说明书

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购买方式

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产品新闻

背景资料

Porcupine (PORCN) is a membrane bound O-acyltransferase that mediates palmitoylation of Wnt family proteins.{27064} This step is required for secretion and biologic activity of Wnt proteins, which have roles in embryonic development and cancer.{27064,27062} IWP-L6 is a potent inhibitor of PORCN (EC50 = 0.5 nM).{27202} It suppresses the phosphorylation of disheveled 2 in HEK293 cells. IWP-L6 displays high stability in human plasma (t1/2 > 24 hours) and in zebrafish, but it is much less stable in plasma from mice and rats.{27202} In zebrafish, IWP-L6 blocks Wnt/β-catenin-dependent developmental processes, including tailfin regeneration and posterior axis formation.{27202} It also completely prevents branching morphogenesis in cultured mouse embryonic kidneys at doses of 50 nM and above, indicating complete inhibition of Wnt signaling.{27202}

产品描述

A potent inhibitor of PORCN (EC50 = 0.5 nM); displays high stability in human plasma (t1/2 > 24 hours) and in zebrafish, but is much less stable in plasma from mice and rats; completely blocks Wnt/β-catenin-dependent developmental processes in zebrafish and in cultured mouse embryonic kidneys

产品形式

A crystalline solid

保存建议

建议您在收到Cayman Chemical品牌的IWP-L6 (5 mg)产品后置于-20度保存，产品有效期为730天.

其他

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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