Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated (HCN) channels contribute to native pacemaker currents in heart and neurons and modulate cardiac and neuronal excitability.{28047} Certain HCN channels also accentuate neuropathic pain.{28043} ZD 7288 is a potent blocker of HCN channels that inhibits HCN4 more potently than HCN1 (IC50s = 32 and 158 nM, respectively).{28045} Through its effects on HCN channels, ZD 7288 modulates the sinoatrial node and slows heart rate.{28049,28044} In addition, ZD 7288 reduces neuropathic pain in several animal models.{28046,28048}
产品描述
A potent blocker of HCN channels that inhibits HCN4 more potently than HCN1 (IC50s = 32 and 158 nM, respectively); modulates the sinoatrial node and slows heart rate; reduces neuropathic pain in several animal models
