Inhibits ubiquitin activating enzyme E1 (>60% inhibition at 10 uM) with little or no activity against E2 or E3. Cell permeable
产品描述
A cell-permeable, irreversible ubiquitin-activating enzyme (E1) inhibitor (IC50 < 10 μM); blocks ubiquitination and prevents ubiquitin-mediated proteasomal degradation; also causes an increase in sumoylation of proteins