中文名称

（3S，6S，12aS）-1,2,3,4,6,7,12,12a-八氢-9-甲氧基-6-（2-甲基丙基）-1,4-二氧代吡嗪并[1'，2 '：1，6]吡啶基[3，4-b]吲哚-3-丙酸1，1-二甲基乙酯

英文名字

(3S,6S,12aS)-1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxo-pyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester

供应商

Cayman Chemical

产品货号

15215-1

产品报价

￥已停产

产品说明书

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购买方式

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产品新闻

背景资料

Breast cancer resistance protein (BCRP) is an ATP-binding cassette protein known also as ABCG2. While it normally functions as a high-capacity urate exporter in the renal system, it also acts as a xenobiotic transporter and contributes to multidrug resistance (e.g., to mitoxantrone) in certain types of cancer.{24807} BCRP is abundant at the intestinal epithelium and blood-brain barrier, potentially restricting the distribution of certain drugs.{24809,24808} Ko 143 is a potent and selective inhibitor of BCRP, preventing the export of mitoxantrone and topotecan in breast cancer cell lines (EC50s = 23 and 26 nM, respectively).{24809} It is much less effective at the transporters P-glycoprotein and multidrug resistance-associated protein 1, MRP1.{24809} Ko 143 is effective in vivo in mice.{24809,24808}

产品描述

A potent and selective inhibitor of BCRP, preventing the export of mitoxantrone and topotecan in breast cancer cell lines (EC50s = 23 and 26 nM, respectively); effective in vivo in mice

产品形式

A crystalline solid

保存建议

建议您在收到Cayman Chemical品牌的Ko 143 (1 mg)产品后置于-20度保存，产品有效期为730天.

其他

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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