- 中文名称
R-Spondin 3, Human, BioAssay DuoSet ELISA Development Kit (Cristin 1, PWTSR, RSPO3, THSD2)
- 英文名字
- R-Spondin 3, Human, BioAssay DuoSet ELISA Development Kit (Cristin 1, PWTSR, RSPO3, THSD2)
- 供应商
- USBiological
- 产品货号
- 145765
- 产品报价
- ￥1/1Kit
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- USBiological品牌是全球有名的抗原抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。武汉艾美捷科技作为USBiological品牌中国区域总代理，是行业中少有的致力于服务客户，帮助客户，且拥有独立的专业销售团队、技术支持团队、市场营销团队、进出口报关团队的高科技生物企业。可以为您提供及时的咨询响应，专业的产品和解决方案支持，稳健快捷的交货周期，优质放心的售后服务。我们致力于为您提供有价值的产品和服务，在意您的成功！
- 产品描述
- R-Spondin 3 (RSPO3, Roof plate-specific Spondin 3), also called cysteine-rich and single thrombospondin domain containing-1 (Cristin 1), is an ~31kD secreted protein that shares ~40% aa identity with the other three R-Spondin family members. All are positive modulators of Wnt/beta-Catenin signaling, but each has a distinct expression pattern (1-4). Like other R-Spondins, R-Spondin 3 contains two adjacent cysteine-rich furin-like domains (amino acids (aa) 35-135) with one potential N-glycosylation site (36aa), followed by a thrombospondin (TSP-1) motif (aa147-207) and a region rich in basic residues (aa211-269). Only the furin-like domains are needed for beta-Catenin stabilization. Within aa21-209, mouse R-Spondin 3 shares 93%, 97%, 96%, 95% and 91% aa identity with human, rat, equine, bovine and canine R-Spondin 3, respectively. Potential isoforms of 217, 224 and 252aa are divergent or truncated at the C terminus; the 252aa form also lacks aa4-33 at the N-terminus. Mouse R-Spondin 3 is critical for development of the placental labyrinthine layer, probably by promoting VEGF expression and thus vascular development. It is also essential for expression of the placenta-specific transcription factor, Gcm1. In the mouse embryo, R-Spondin 3 is often expressed by or located near endothelial cells. It is found in the roof plate, tail, somites, otic vesicles, cephalic mesoderm, truncus arteriosus, atrioventricular canal of the developing heart, and strongly but transiently in developing limbs. R-Spondins regulate Wnt/beta-Catenin by competing with the Wnt antagonist Dkk-1 for binding to the Wnt co-receptors LRP-6 and Kremen, reducing their Dkk-1-mediated internalization.Sample Type:Cell culture supernatesIntended Use:This BioAssay DuoSet ELISA Development kit contains the basic components required for the development of sandwich ELISAs to measure natural and recombinant human Roof Plate-specific Spondin 3 (R-Spondin 3). DuoSets are designed for the analysis of cell culture supernates. Range:~15.6-1000pg/mlSpecificity:Recognizes natural and recombinant human Roof Plate-specific Spondin 3 (R-Spondin 3).Kit Components:Sheep anti-human R-Spondin 3 capture antibody, 1x vialBiotinylated sheep anti-human R-Spondin 3 detection antibody, 1x vialRecombinant human R-Spondin 3 standard, 1x3 vialsStreptavidin-HRP, 1x vialStorage and Stability:Store other components at 4°C. Stable for 6 months For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- 产品特点
- 针对R-Spondin 3, Human, BioAssay DuoSet ELISA Development Kit (Cristin 1, PWTSR, RSPO3, THSD2)该产品的特点优势，欢迎查阅官网提供的产品说明书。
- 保存建议
- 建议收到R-Spondin 3, Human, BioAssay DuoSet ELISA Development Kit (Cristin 1, PWTSR, RSPO3, THSD2)产品后将其置于4°C/-20°C保存。
- 其他
- Usbiological公司是美国著名的抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。Usbiological公司现已拥有超过50,19234种抗体、抗原和生化产品，为科研用户提供了诸多超值选择。
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- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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