- 中文名称
Phospho-p38 alpha (T180/Y182) BioAssay DuoSet IC ELISA Kit (MAPK14, SAPK2a)
- 英文名字
- Phospho-p38 alpha (T180/Y182) BioAssay DuoSet IC ELISA Kit (MAPK14, SAPK2a)
- 供应商
- USBiological
- 产品货号
- 145759
- 产品报价
- ￥1/1Kit
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- USBiological品牌是全球有名的抗原抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。武汉艾美捷科技作为USBiological品牌中国区域总代理，是行业中少有的致力于服务客户，帮助客户，且拥有独立的专业销售团队、技术支持团队、市场营销团队、进出口报关团队的高科技生物企业。可以为您提供及时的咨询响应，专业的产品和解决方案支持，稳健快捷的交货周期，优质放心的售后服务。我们致力于为您提供有价值的产品和服务，在意您的成功！
- 产品描述
- The p38 Mitogen-activated Protein Kinases (MAPKs) are a family of four related Ser/Thr kinases activated by proinflammatory cytokines and environmental stresses. All four p38 family members, alpha, beta, gamma, and delta, are phosphorylated by MKK3 and/or MKK6 at dual Thr and Tyr positions within the phosphoacceptor sequence Thr-Gly-Tyr. Once activated, p38 phosphorylates a number of targets, including the nuclear transcription factors ATF2 and Max.The most frequently analyzed family member, p38 alpha, also known as SAPK2a and MAPK14, was initially purified as a kinase critical to the signaling cascade linking IL-1 to MAPKAPK-2 and the small heat shock protein HSP27. Ubiquitously expressed, p38 alpha is dually phosphorylated by MKK3 and MKK6 at Thr180 and Tyr182. Once activated, p38 alpha phosphorylates a number of targets, including the cytoplasmic kinases MNK 4 and PRAK5 and the nuclear transcription factors ATF2 1 and STAT1. Several promising compounds that inhibit p38 alpha are being investigated as potential therapies for arthritic and inflammatory diseases.Sample Type:Cell lysatesRange:~62.5-4000pg/mlSpecificity:The human/mouse/rat Phospho-p38a ELISA kit specifically recognizes phosphorylated p38a. Specificity was demonstrated by Western blot analysis of the protein bound by the capture antibody supplied in the kit.Test Principle:The BioAssay ELISA kit contains the basic components required for the development of sandwich ELISAs to measure p38a phosphorylated at T180/Y182 in cell lysates. An immobilized capture antibody specific for p38a binds both phosphorylated and unphosphorylated p38a. After washing away unbound material, a biotinylated detection antibody specific for p38a dually phosphorylated at T180 and Y182 is used to detect captured protein, utilizing a standard Streptavidin-HRP format.Kit Components:Phospho-p38a Capture Antibody, 1x vialPhospho-p38a Detection Antibody, 1x vialPhospho-p38a Standard, 3x vialsStreptavidin-HRP, 1x vialStorage and Stability:Store powder at 4°C. Store other components at 4°C. Stable for at least 6 months For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- 产品特点
- 针对Phospho-p38 alpha (T180/Y182) BioAssay DuoSet IC ELISA Kit (MAPK14, SAPK2a)该产品的特点优势，欢迎查阅官网提供的产品说明书。
- 保存建议
- 建议收到Phospho-p38 alpha (T180/Y182) BioAssay DuoSet IC ELISA Kit (MAPK14, SAPK2a)产品后将其置于4°C保存。
- 其他
- Usbiological公司是美国著名的抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。Usbiological公司现已拥有超过50,19234种抗体、抗原和生化产品，为科研用户提供了诸多超值选择。
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- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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