TRPP3 channel inhibitor (IC50=0.14um). Also inhibits epithelial Na+ channels (Kd=0.4nm for a high affinity site on the epithelial Na+ channel). Derivative of amiloride.Sequence:C12H12ClN7O.CH3SO3HSolubility:DMSO (~100mM)Molecular Weight:~401.83Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
