中文名称

L-（+）-2-氨基-4-磷酸丁酸| L-APB；2S-氨基-4-膦酰基丁酸

英文名字

L-(+)-2-amino-4-phosphorobutanoic acid|L-APB; 2S-amino-4-phosphono-butanoic acid

供应商

Cayman Chemical

产品货号

14538-5

产品报价

￥询价/5mg

产品说明书

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购买方式

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产品新闻

背景资料

Metabotropic glutamate receptors (mGluR) function to modulate excitatory synaptic transmission in the brain. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. L-AP4, an analog of L-glutamic acid, is a selective Group III mGluR agonist that functions presynaptically to suppress glutamate release (IC50 = 2.5 μM).{22831,22827,21634} L-AP4 has been shown to depress synaptic transmission in glutamatergic pathways in the hippocampus, olfactory bulb, and retina as well as act as an agonist at the quisqualate-sensitized AP6 site in hippocampus.{22831}

产品描述

A selective Group III metabotropic glutamate receptor agonist that functions presynaptically to suppress glutamate release (IC50 = 2.5 μM); depresses synaptic transmission in glutamatergic pathways in the hippocampus, olfactory bulb, and retina

产品形式

A white to off-white solid

保存建议

建议您在收到Cayman Chemical品牌的L-AP4 (5 mg)产品后置于4度保存，产品有效期为180天.

其他

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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