PNU-120596 is a positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor (nAChR), increasing agonist-evoked calcium flux (EC50 = 216 nM).{29718} It has no detectable effect on α4β2, α3β4, or α9β10 nAChRs. PNU-120596 increases the frequency of ACh-evoked GABAergic postsynaptic currents in rat hippocampal slices and improves the auditory gating deficit caused by amphetamine in rats.{29718,29720} It also reduces the cortical/subcortical infarct volume caused by transient focal cerebral ischemia in rats.{29719}
产品描述
A positive allosteric modulator of the α7 neuronal nAChR, increasing agonist-evoked calcium flux (EC50 = 216 nM); increases the frequency of ACh-evoked GABAergic postsynaptic currents in rat hippocampal slices and improves the auditory gating deficit caused by amphetamine in rats
