中文名称

quino [2'，3'：3,4] pyrrolo [2,1-b] quinazolin-11（13H）-one

英文名字

quino[2',3':3,4]pyrrolo[2,1-b]quinazolin-11(13H)-one

供应商

Cayman Chemical

产品货号

14253-25

产品报价

￥已停产

产品说明书

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购买方式

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产品新闻

背景资料

Luotonin A is an alkaloid originally isolated from a plant used in traditional Chinese medicine.{22184} It inhibits the growth of mouse leukemia P388 cells (IC50 = 1.8 μg/ml).{22184} Luotonin A is structurally similar to the alkaloid camptothecin (Item No. 11694) and, like camptothecin, it binds to and stabilizes the topoisomerase I-DNA binary complex, leading to DNA breakage and cell death (IC50 = 5.07-12.6 μM).{25352} Also like camptothecin, luotonin A forms non-covalent complexes with double-stranded DNA in the minor groove and this association can be followed by native fluorescence associated with the aromatic and heterocyclic ring structure.{25350} Luotonin A also selectively inhibits the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2 (IC50 = ~6 μM for each) in human liver microsomes.{25351}

产品描述

An alkaloid that inhibits the growth of mouse leukemia P388 cells (IC50 = 1.8 μg/ml); binds to and stabilizes the topoisomerase I-DNA binary complex, leading to DNA breakage and cell death (IC50 = 5.07-12.6 μM); selectively inhibits CYP1A1 and CYP1A2 (IC50 = ~6 μM for each) in human liver microsomes

产品形式

A crystalline solid

保存建议

建议您在收到Cayman Chemical品牌的Luotonin A (25 mg)产品后置于-20度保存，产品有效期为730天.

其他

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

注意

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