- 中文名称
N-methyl Leukotriene C4 (500 ug)
- 英文名字
- N-methyl LTC4, N-methyl Leukotriene C4, N-methyl-5S-hydroxy-6R-(S-glutathionyl)-7E,9E,11Z,14Z-eicosatetraenoic acid
- 供应商
- Cayman
- 产品货号
- 13390-500
- 产品报价
- ￥30016/500 ug
- 产品说明书
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- 购买方式
- 产品新闻
- 背景资料
- Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 -LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. It is one of the constituents of slow-reacting substance of anaphylaxis -SRS-A) and exhibits potent smooth muscle contracting activity. LTC4, however, is rapidly metabolized to LTD4 and LTE4, which makes the characterization of LTC4 pharmacology difficult. N-methyl LTC4 is a synthetic analog of LTC4 that is not readily metabolized to LTD4 and LTE4.It acts as a potent and selective CysLT2 receptor agonist exhibiting EC50 values of 122 and > 2,000 nM at the human CysLT2 and CysLT1 receptors, respectively. It has essentially the same potency as LTC4 at both the human and murine receptors CysLT2 receptors. N-methyl LTC4 is potent and active in vivo, causing vascular leak in mice overexpressing the human CysLT2 receptor but not in CysLT2 receptor knockout mice.
- 产品描述
- A stable analog of LTC4 that does not readily metabolize to LTD4 and LTE4 at the expense of marginally reduced biological activity
- 产品形式
- 保存建议
- -80
- 其他
- Cayman Chemical
- 注意
-
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