中文名称

KN-93 (25 mg)

英文名字

KN-93, N-[2-[[[3-(4-chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxy-benzenesulfonamide

供应商

Cayman

产品货号

13319-25

产品报价

￥21070/25 mg

产品说明书

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产品新闻

背景资料

KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II -CaMKII), competitively blocking CaM binding to the kinase -Ki = 370 nM). It does not affect the activities of PKA, PKC, MLCK, or Ca2+-phosphodiesterase. It inhibits histamine-induced aminopyrine uptake in parietal cells -IC50 = 300 nM). More recently, KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1

产品描述

A selective inhibitor of Ca2+/calmodulin-dependent kinase II -CaMKII), competitively blocking CaM binding to the kinase -Ki = 370 nM); inhibits histamine-induced aminopyrine uptake in parietal cells -IC50 = 300 nM)

产品形式

保存建议

-20

其他

Cayman Chemical

注意

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