Glucose transporter 1 (GLUT1) is an inducible carrier of pentoses and hexoses, including glucose. STF-31 is an inhibitor of GLUT1 (IC50 = ~1 µM) that blocks glucose uptake.{20157} It induces necrosis in cancer cells that lack the von Hippel-Lindau tumor suppressor gene, which overexpress GLUT1.{20157} Although STF-31 binds GLUT1, suggesting a direct effect, STF-31 also inhibits nicotinamide phosphoribosyltransferase, an enzyme that induces GLUT1 expression.{20157,28328,28326} STF-31 is also toxic to human pluripotent stem cells (hPSCs) and can be used to selectively eliminate hPSCs from mixed cultures.{28327}
产品描述
An inhibitor of GLUT1 (IC50 = ~1 µM) that blocks glucose uptake and induces necrosis in cancer cells that lack VHL; inhibits NAMPT, an enzyme that induces GLUT1 expression; toxic to hPSCs and can be used to selectively eliminate hPSCs from mixed cultures
