Lamin C is intermediate filament protein localized to the inner nuclear membrane. It is expressed predominantly in terminally differentiated cells and defines the shape and stability of nuclei in mammalian cells. Besides their structural roles, lamin proteins also regulate fundamental aspects of nuclear function and they cross-talk with cell signaling cascades and cell metabolism. Mutations of LMNA gene, encoding lamin A and C proteins, are often associated with pathogenesis of respective cell types, such as of heart myocytes.
应用类型
IP, WB, ICC
免疫原
来源宿主
小鼠
反应性
Human, Mouse
保存建议
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.
