Grb2 (growth factor receptor-bound protein 2) is a highly conserved adaptor protein composed of central SH2 domain flanked by two terminal SH3 domains. Grb2 mediates coupling of receptor protein tyrosine kinases to a guanine nucleotide exchange factor Sos, thereby enabling the tyrosine kinases to stimulate activity of Ras and hence of MAP kinase pathway. Grb2 also can bind to receptor protein tyrosine phosphatases and affect their signaling.
应用类型
WB
免疫原
Synthetic peptide corresponding to C-terminus of human Grb2 (amino acids 198-217).
来源宿主
兔
反应性
Human
保存建议
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.
