GABA B receptor is a G-protein-coupled inhibitory receptor of gamma-aminobutyric acid (GABA), and has important functions in brain by inhibition of adenylyl cyclase and modulation of G-protein-gated Ca2+ and K+ channels. GABA B receptor is comprised of two subunits, GB1 and GB2 with N-terminal extracellular and C-terminal intracellular domains. The GB1 subunit plays a critical role in ligand binding, whereas the GB2 subunit contains the determinants required for G-protein signaling. Multiple allosteric interactions between the two subunits are required for correct functioning of the receptor. There are two N-terminal splice variants of GB1 subunit, termed GB1a and GB1b; their expression in the central nervous system changes during the ontogenesis and differs between various regions of the brain.
应用类型
WB, ICC
免疫原
Synthetic peptide (coupled with THG) derived from aminoacid sequence 100-124 of mouse GABA B receptor 1. The sequence has 100% homology with rat and human.
来源宿主
兔
反应性
Mouse, Rat
保存建议
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.
