CD11c (p150, alphaX integrin subunit) forms complex with CD18 (beta2 integrin subunit) and is expressed mainly on tissue macrophages and dendritic cells. CD11c binds to complement fragment iC3b, fibrinogen, VCAM-1 and ICAM-2 or e.g. CD90. Like other beta2 integrins, CD11c/CD18 plays roles in cell migration and phagocytosis. Moreover, interaction of CD11c/CD18 with plasminogen regulates plasmin activities, and interaction with heparin counteracts binding of iC3b.
应用类型
FC (QC tested), IP, IHC(F)
免疫原
Dendritic cells of synovial fluid
来源宿主
小鼠
反应性
Human, Monkey
保存建议
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.
