Serine/threonine protein kinase Akt/PKB (Protein Kinase B) plays important roles in cell growth, metabolism, proliferation and survival. Upon extracellular stimulus that leads to activation of phosphatidylinositol 3-kinase (PI3K), Akt is recruited from the cytosol to the plasma membrane through binding 3?phosphoinositides and is phosphorylated. Active Akt dissociates from the plasma membrane to gain access to various substrates in different subcellular locations by translocating to cytosol and nucleus.
应用类型
WB
免疫原
Synthetic peptide (coupled with KLH) derived from aminoacid sequence 85-100 of human Akt1. This immunogen sequence has 100% homology with mouse and rat Akt1/PKB.
来源宿主
兔
反应性
Human
保存建议
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.
