STIM1 (stromal interacting molecule; also known as GOK) acts as a sensor of calcium depletion within the endoplasmic reticulum and transduces the signal to Orai1, the presumptive CRAC channel at the plasma membrane. Following decrease of luminal calcium concentration, STIM1 oligomerizes and induces Orai1 to enable entry of extracellular calcium into the cytoplasm. However, the precise mechanism of STIM1-Orai1 interaction has not been elucidated yet. Many questions also remain to be solved around STIM1 functional distribution. It turns out that STIM1 associates with growing ends of microtubules and is involved in endoplasmic reticulum tubule extension.
应用类型
IP, WB, IHC(P), ICC
免疫原
Synthetized peptide (C-terminal cytoplasmic part of STIM1).
来源宿主
小鼠
反应性
Rat, Human, Mouse
保存建议
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.
