CD13 (aminopeptidase N, APN) is a 150 kDa type II transmembrane zinc-binding ectopeptidase expressed on various cell types. This metalloprotease preferentially catalyzes removal of neutral amino acids from small peptides, thus activating or inactivating bioactive peptides. CD13 has also role in extracellular matrix degradation, antigen processing and signal transduction, is important in inflammatory responses, regulates intercellular contact, cell motility and vascularization. CD13 is involved in protection of leukemic cells against apoptosis and its expression associated with poor prognosis of carcinomas.
应用类型
FC (QC tested), IP, IHC(F)
免疫原
Human AML cells
来源宿主
小鼠
反应性
Human, Non-human primates
保存建议
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.
