C-terminal Src kinase (Csk) is a non-receptor protein tyrosine kinase which resembles Src-family kinases, but unlike them lacks the conserved autophosphorylation site, the regulatory C-terminal tyrosine as well as myristylation and palmitylation. Csk negatively regulates Src-family kinases by phosphorylation of their C-terminal regulatory tyrosine. Disruption of the csk gene causes constitutive activation of Src-family kinases, and overexpression of Csk usually counteracts their signaling. The Csk-mediated regulation of those Src-family kinases that are localized in lipid rafts is enabled by a ubiquitously expressed transmembrane adaptor PAG (also known as Cbp, Csk-binding protein), which recruits Csk.
应用类型
WB, IP, ICC
免疫原
Bacterially expressed recombinant fragment of human Csk corresponding to aa 330-450.
来源宿主
小鼠
反应性
Human, Mouse
保存建议
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.
