CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands.
应用类型
FC (QC tested), IHC(F)
免疫原
IM9 human B-lymphoblastoid cell line
来源宿主
小鼠
反应性
Pig, Human, Dog, Cow
保存建议
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.
