CD274 / PD-L1 (programmed death ligand-1), also known as B7-H1, is a member of the B7 family of regulatory proteins. It can act as both costimulatory and coinhibitory molecule for T cells. Interaction with its ligand CD279 (PD1) appears to be important in the maintenance of peripheral tolerance and in prevention of tumor rejection. Even pathogens (e.g. Schistosoma) may exploit CD274 to evade an immune response. Besides CD279, existence of other receptor(s) for CD274 is likely.
应用类型
FC (QC tested), IHC(F)
免疫原
Full length human CD274
来源宿主
小鼠
反应性
Non-human primates, Human
保存建议
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.
