CD279 / PD-1 (programmed cell death 1), a transmembrane protein of CD28/CTLA-4 family. It is expressed inducibly mainly on activated T, B, and myeloid cells and plays a role in maintaining peripheral self-tolerance. Binding to its receptors CD273 and CD274 is associated with inhibition of T cell proliferation and induction of their anergy. It is also expressed during thymic development. Some variants of CD279 are associated with susceptibility to systemic lupus erythematosus, type 1 diabetes, and rheumatoid arthritis.
应用类型
FC (QC tested), IHC(F)
免疫原
来源宿主
小鼠
反应性
Non-human primates, Human
保存建议
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.
