CD170, also known as Siglec 5 (sialic acid binding Ig-like lectin 5) is a type 1 transmembrane glycoprotein containing two cytoplasmic immunoreceptor tyrosine inhibitory motifs (ITIMs). CD170 forms homodimers and functions as an inhibitory receptor able to downregulate cell activation. It binds to alpha2,3- and alpha2,6-linked sialic acid ligands, e.g. on glycophorin A (CD235a). Aberrant expression of CD170 by CD34+ progenitor cells can be observed in case of acute myeloid leukemias.
应用类型
FC (QC tested), IP, IHC(F), ICC, ELISA
免疫原
Fusion protein composed of human CD170 extracellular domain and Fc region of human IgG1
来源宿主
小鼠
反应性
Non-human primates, Human
保存建议
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.
